Journal: Bioactive Materials
Article Title: Facile and rapid fabrication of a novel 3D-printable, visible light-crosslinkable and bioactive polythiourethane for large-to-massive rotator cuff tendon repair
doi: 10.1016/j.bioactmat.2024.03.036
Figure Lengend Snippet: Accelerated degradation and swelling studies of PHT polymer. PHT polymer degraded slowly under alkaline, acidic, and oxidizing conditions. (a) Experimental design of accelerated degradation and swelling studies. (b) Swelling ratio of PHT polymers under aqueous (HBSS), alkaline (5 N NaOH) and acidic (1 N HCl) conditions after 4 h at room temperature (n = 6 for each group; 1 independent experiment). (c) Accelerated degradation of PHT polymers under alkaline (5 N sodium hydroxide/NaOH), acidic (2 N hydrochloric acid/HCl), and oxidizing (30% hydrogen peroxide/H 2 O 2 ) conditions at room temperature over 5 days or 1 week (5 N NaOH – PHT polymer: n = 28, ADM: n = 9, 2 N HCl – PHT polymer: n = 14, ADM: n = 9, 30% H 2 O 2 – PHT polymer: n = 6, ADM: n = 3; 1–2 independent experiments). ****: p ≤ 0.0001; statistical significance was relative to ADM. (d) Percentage change in tensile strength, tensile modulus, and failure strain following 1-week incubation in 2 N HCl (PHT polymer: n = 14, ADM: n = 6; 1 independent experiment). Error bars indicate standard error of mean.
Article Snippet: Samples were washed with 5 N NaOH (Thermofisher, USA) for 1 h and 1 × phosphate buffered saline (PBS; Thermofisher, USA) buffer three times.
Techniques: Polymer, Incubation
